Cardioprotective Activity of Ethanolic Extract of Terminalia arjuna in Isoproterenol-Induced Rats

Dr. Ch. Maheshwara Reddy; Dr M. Balaji Yadav; G. Indira Priya Darshini; Dr. K. Mangulal

pdf

Published: Feb 27, 2023

Keywords:

myocardial infarction (MI).

Dr. Ch. Maheshwara Reddy

Dr M. Balaji Yadav

G. Indira Priya Darshini

Dr. K. Mangulal

Abstract

One of the main reasons for the high mortality rate worldwide is myocardial infarction (MI). We describe how Partharishtam, an
Ayurvedic polyherbal formulation, protects albino rats against myoproterenol-induced myocardial infarction. Significant alterations in
important biomolecules measured in blood serum and cardiac tissues indicate that isoproterenol causes MI in normal albino rats. In
terms of some of the known identifying markers of MI, including Troponin I and T, creatine phosphokinase serum (CPK-S), creatine
phosphokinase myoglobulin isozyme fraction (CPK-MB), and oxidative enzymes like superoxide dismutase (SOD), reduced glutathione
(GSH), and catalase, the cardioprotective effects of Partharishtam and the standard medication Propranolol were compared. Troponin 1
and T, CPK-S, and CPK-MB levels significantly decreased in isoproterenol-induced MI rats after partharishtam therapy. Studies using in
vivo antioxidant enzymes also showed that when Partharishtam was administered to MI rats, the levels of SOD, GSH, and catalase
increased to almost normal levels. This is quite similar to the widely used medication Propranolol, which is used to treat MI humans. In
a rat model, histopathological research validated Partharistham's cardioprotective qualities. When Partharishtam was tested on healthy
rats, we found no toxicity or adverse effects. Partharishtam, a polyherbal compound, may thus be regarded as a safe medication for
MI. Key words: creatine phosphokinase, SOD, GSH, catalase, partharishtam, polyherbal, isoproterenol, propranolol, troponin I, troponin
T, and myocardial infarction.

Issue

Vol. 60 No. 2 (2023)

Section

Articles

This work is licensed under a Creative Commons Attribution 4.0 International License.

Announcements

Urgent Regarding ISSN Update

Announcement Date: April 20, 2021

Dear Authors and Researchers,
We would like to inform you that the U.S. ISSN Center at the Library of Congress has confirmed that the correct ISSN number of the Journal Psychology and Education is ISSN 1553-6939. This ISSN is to be used instead of ISSN 0033-3077 which is the ISSN that belongs to the former title, “Psychology.” Each time a journal undergoes a major change of title a new ISSN is assigned. Psychology and Education also has been assigned a Linking ISSN (ISSN-L). The ISSN-L is available for use when there is a need to identify and link to a continuing resource without regard to format, for example in services such as OpenURL, library catalogues, search engines or knowledge bases. The next issue of Psychology and Education will be published with ISSN 1553-6969. But the previous ISSN will be also available in the ISSN Portal to retrieve the record for Psychology because it remains the identifier for the former title Psychology and the articles published under that title.

Imp. Notice

Announcement Date: January 11, 2021

Note: Dear Authors and researchers, We found that some of the organizations or individuals are giving fake acceptance letters on behalf of the journal "PSYCHOLOGY AND EDUCATION" and they are illegally using the logo and signature of the editor. We suggest you to alert from such agents or organizations. We are not responsible for any acceptances provided by any agents regarding journal. Also journal will not take any responsibility for payments made to any such acceptances to third parties, agents or conferences.

Call for Reviewers

Announcement Date: December 23, 2020

Call for Editorial Member/ Reviewers Submitting your Application
If you would like to apply for the position of an Editorial Board Member on the journal, please contact the Editor including your CV and a brief covering letter detailing why you are a suitable candidate, to editor@psychologyandeducation.net. Your cover letter should be no longer than one page and should cover where you believe the research field is going (and the journal's place within it), as well as details of any previous relevant journal editorial and peer review management experience.

Article Sidebar

Main Article Content

Abstract

Article Details